We gratefully acknowledge financial support from the NSF/EPSCoR under grant nos. 2001RII-EPS-0132573 and 2004RII-EPS-0447660, NSF CAREER grant no. CHE-0547846, NIH grant no. 1R01M081040, and NSF EFRI grant no. ENG-0736007.
Ratiometric Single-Nanoparticle Oxygen Sensors for Biological Imaging†
Article first published online: 27 FEB 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 15, pages 2741–2745, March 30, 2009
How to Cite
Wu, C., Bull, B., Christensen, K. and McNeill, J. (2009), Ratiometric Single-Nanoparticle Oxygen Sensors for Biological Imaging . Angew. Chem. Int. Ed., 48: 2741–2745. doi: 10.1002/anie.200805894
- Issue published online: 24 MAR 2009
- Article first published online: 27 FEB 2009
- Manuscript Received: 3 DEC 2008
- NSF/EPSCoR. Grant Numbers: 2001RII-EPS-0132573, 2004RII-EPS-0447660
- NIH. Grant Number: 1R01M081040
- NSF. Grant Number: ENG-0736007
- fluorescent probes;
It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration.