We gratefully acknowledge financial support from the NSF/EPSCoR under grant nos. 2001RII-EPS-0132573 and 2004RII-EPS-0447660, NSF CAREER grant no. CHE-0547846, NIH grant no. 1R01M081040, and NSF EFRI grant no. ENG-0736007.
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Communication
Ratiometric Single-Nanoparticle Oxygen Sensors for Biological Imaging†
Article first published online: 27 FEB 2009
DOI: 10.1002/anie.200805894
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wu, C., Bull, B., Christensen, K. and McNeill, J. (2009), Ratiometric Single-Nanoparticle Oxygen Sensors for Biological Imaging. Angew. Chem. Int. Ed., 48: 2741–2745. doi: 10.1002/anie.200805894
- †
Publication History
- Issue published online: 24 MAR 2009
- Article first published online: 27 FEB 2009
- Manuscript Received: 3 DEC 2008
Funded by
- NSF/EPSCoR. Grant Numbers: 2001RII-EPS-0132573, 2004RII-EPS-0447660
- NIH. Grant Number: 1R01M081040
- NSF. Grant Number: ENG-0736007
- Abstract
- Article
- References
- Cited By
Keywords:
- fluorescent probes;
- FRET;
- nanostructures;
- polymers;
- sensors
Abstract
It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration.