Get access

Air-Stable {(C5H5)Co} Catalysts for [2+2+2] Cycloadditions


  • This work was supported by CNRS, MRES, IUF, and DGA.


Cobalt cyclopentadienyl complexes incorporating a fumarate and a CO ligand (see picture) efficiently catalyze inter- and intramolecular [2+2+2] cycloadditions of alkynes, nitriles, and/or alkenes to give benzenes, pyridines, or 1,3-cyclohexadienes. Unlike catalysts such as [CpCo(CO)2] or [CpCo(C2H4)2] (Cp=C5H5), they are air-stable, easy to handle, compatible with microwave conditions, and do not necessarily require irradiation to be active.

original image