Selective C[BOND]F Bond Activation of Tetrafluorobenzenes by Nickel(0) with a Nitrogen Donor Analogous to N-Heterocyclic Carbenes


  • We acknowledge NSERC for a research discovery grant and for a postgraduate scholarship for M.E.D.


N, not NHC: A neutral, basic, strong σ-donor nitrogen ancillary ligand with properties analogous to those of N-heterocyclic carbenes (NHCs) was developed to aid in the oxidative additions of challenging substrates to late transition metals. Selective, room-temperature C[BOND]F bond activation was observed with hexa-, penta-, and all three isomers of tetrafluorobenzene using a nickel(0) source in the presence of this donor.

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