Communication

Silver Nanoparticle Formation in Different Sizes Induced by Peptides Identified within Split-and-Mix Libraries†

  1. Kirsten Belser Dr.2,
  2. Tünde Vig Slenters Dipl.-Chem.1,
  3. Conelious Pfumbidzai2,
  4. Grégory Upert Dr.2,
  5. Laurent Mirolo1,
  6. Katharina M. Fromm Prof. Dr.1,
  7. Helma Wennemers Prof. Dr.2

Article first published online: 16 APR 2009

DOI: 10.1002/anie.200806265

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 20, pages 3661–3664, May 4, 2009

Additional Information

How to Cite

Belser, K., Vig Slenters, T., Pfumbidzai, C., Upert, G., Mirolo, L., Fromm, K. and Wennemers, H. (2009), Silver Nanoparticle Formation in Different Sizes Induced by Peptides Identified within Split-and-Mix Libraries. Angewandte Chemie International Edition, 48: 3661–3664. doi: 10.1002/anie.200806265

Author Information

  1. 1

    Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg (Switzerland), Fax: (+41) 26-300-9738

  2. 2

    Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel (Switzerland), Fax: (+41) 61-267-0976, http://www.chemie.unibas.ch/∼wennemer/index.html

  1. †

    K.B. and T.V.S. contributed equally to this work. Support from Bachem, the Swiss National Science Foundation, the NCCR NANO, FriMat, and the RTN “REVCAT” by the European Union is gratefully acknowledged. We thank G. Morson, M. Düggelin, and D. Mathys of the ZMB Basel and J. S. Agustsson, Dr. M. Calame, and Prof. Dr. C. Schönenberger for help in recording the SEM images. H.W. thanks Bachem for an endowed professorship.

Publication History

  1. Issue published online: 28 APR 2009
  2. Article first published online: 16 APR 2009
  3. Manuscript Received: 22 DEC 2008

Funded by

  • Bachem
  • Swiss National Science Foundation
  • NCCR NANO
  • European Union

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Keywords:

  • combinatorial chemistry;
  • nanostructures;
  • peptides;
  • silver;
  • solid-phase synthesis

Graphical Abstract

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Split-and-mix libraries are an excellent tool for the identification of peptides that induce the formation of Ag nanoparticles in the presence of either light or sodium ascorbate to reduce Ag+ ions. Structurally diverse peptides were detected in colorimetric on-bead screenings that generate Ag nanoparticles of different sizes, as confirmed by SEM and X-ray powder diffraction studies.

Abstract

Split-and-mix libraries are an excellent tool for the identification of peptides that induce the formation of Ag nanoparticles in the presence of either light or sodium ascorbate to reduce Ag+ ions. Structurally diverse peptides were detected in colorimetric on-bead screenings that generate Ag nanoparticles of different sizes, as confirmed by SEM and X-ray powder diffraction studies.

View Full Article with Supporting Information (HTML) Get PDF (610K)