This work was funded by a grant from the National Institutes of Health. We are grateful to Pfizer for additional support of our program.
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Communication
A Stereoselective Synthesis of the Bromopyrrole Natural Product (−)-Agelastatin A†
Article first published online: 17 APR 2009
DOI: 10.1002/anie.200806292
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wehn, P. and Du Bois, J. (2009), A Stereoselective Synthesis of the Bromopyrrole Natural Product (−)-Agelastatin A. Angewandte Chemie International Edition, 48: 3802–3805. doi: 10.1002/anie.200806292
- †
Publication History
- Issue published online: 4 MAY 2009
- Article first published online: 17 APR 2009
- Manuscript Received: 23 DEC 2008
Funded by
- National Institutes of Health
Keywords:
- aziridination;
- bromopyrroles;
- homogeneous catalysis;
- rhodium;
- total synthesis
Graphical Abstract
Weaving an intricate web: A stereoselective synthesis of (−)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.
Abstract
Weaving an intricate web: A stereoselective synthesis of (−)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.