A Stereoselective Synthesis of the Bromopyrrole Natural Product (−)-Agelastatin A


  • This work was funded by a grant from the National Institutes of Health. We are grateful to Pfizer for additional support of our program.


Weaving an intricate web: A stereoselective synthesis of (−)-agelastatin A has been developed, which requires 11 steps from commercially available starting material. The application of a Rh-catalyzed intramolecular olefin aziridination reaction and the subsequent manipulation of the resulting tricyclic intermediate (see scheme) punctuate this study.

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