Iridium Catalysis for C[BOND]H Bond Arylation of Heteroarenes with Iodoarenes


  • This work was supported by the PRESTO program of JST, and a Grant-in-Aid for Scientific Research from MEXT and JSPS. B.J. is a recipient of a JSPS Postdoctoral Fellowship.


Efficient couplings using equimolar quantities of each coupling partner and multiple C[BOND]H bond arylation reactions are achieved with an Ir-based catalytic system for the C[BOND]H bond arylation of electron-rich heteroarenes with iodoarenes to construct extended π-systems. The dramatic ligand effect on reaction efficiency leads to the discovery that Crabtree's catalyst (see scheme) is the optimal catalyst precursor.

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