SEARCH

SEARCH BY CITATION

Keywords:

  • α-synuclein;
  • amyloid fibrils;
  • electron microscopy;
  • NMR spectroscopy;
  • proteins
Thumbnail image of graphical abstract

Amyloid fibrils are filamentous aggregates of peptides and proteins with exceptional stability that are associated with several neurodegenerative diseases. M. Zweckstetter et al. demonstrate in their Communication on page 5046 ff. that amyloid fibrils formed by the protein α-synuclein, which is associated with Parkinson's disease, are rapidly denatured, that is, dissociated and lose the conformation of the constituent protein molecules, in supercooled water at −15 °C, conditions in which many globular proteins remain folded.