A two-peptide lantibiotic … is active against certain pathogenic bacteria in nanomolar concentrations. In their Communication on page 9472 ff., J. C. Vederas and co-workers describe the first solid-supported synthesis of lacticin 3147, the bis(desmethyl) analogue of lacticin A2. This compound shows potent synergistic antimicrobial activity in the presence of lacticin A1. Other lantibiotics can be prepared for the study of structure–activity relationships by using this strategy. Annie Tykwinski is thanked for the cover graphic design.