1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Cover Picture: Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process (Angew. Chem. Int. Ed. 3/2009)
Article first published online: 29 DEC 2008
DOI: 10.1002/anie.200890287
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Bejot, R., Fowler, T., Carroll, L., Boldon, S., Moore, Jane E., Declerck, J. and Gouverneur, V. (2009), Cover Picture: Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process (Angew. Chem. Int. Ed. 3/2009). Angew. Chem. Int. Ed., 48: 413. doi: 10.1002/anie.200890287
Publication History
- Issue published online: 29 DEC 2008
- Article first published online: 29 DEC 2008
Keywords:
- fluorine;
- positron emission tomography;
- radiopharmaceuticals;
- synthetic methods
Time is of the essence in preparing 18F-labeled radiotracers when the half-life of 18F is 109.7 minutes. In their Communication on page 586, V. Gouverneur and co-workers report the radiosynthesis of various prosthetic groups and 18F radiotracers from fluorous-tagged precursors. This approach allows for fast and convenient purification of 18F-radiolabeled material (FSPE=fluorous solid phase extraction). Cover illustration produced by Dr. Karl Harrison (Chemistry Department, University of Oxford).