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Cover Picture: Fluorous Synthesis of 18F Radiotracers with the [18F]Fluoride Ion: Nucleophilic Fluorination as the Detagging Process (Angew. Chem. Int. Ed. 3/2009)



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Time is of the essence in preparing 18F-labeled radiotracers when the half-life of 18F is 109.7 minutes. In their Communication on page 586, V. Gouverneur and co-workers report the radiosynthesis of various prosthetic groups and 18F radiotracers from fluorous-tagged precursors. This approach allows for fast and convenient purification of 18F-radiolabeled material (FSPE=fluorous solid phase extraction). Cover illustration produced by Dr. Karl Harrison (Chemistry Department, University of Oxford).