A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles

Authors

  • Hao Wang Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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    • These authors contributed equally to the work.

  • Shutao Wang Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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    • These authors contributed equally to the work.

  • Helen Su Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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    • These authors contributed equally to the work.

  • Kuan-Ju Chen,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Amanda Lee Armijo,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Wei-Yu Lin Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Yanju Wang Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Jing Sun Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Ken-ichiro Kamei Dr.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Johannes Czernin Prof.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Caius G. Radu Prof.,

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • Hsian-Rong Tseng Prof.

    1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095 (USA), Fax: (+1) 310-206-8975
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  • H. R.T. and C.G.R. acknowledge support from the NIH-NCI NanoSystems Biology Cancer Center (U54A119347).

Abstract

A supramolecular approach has been developed for the preparation of supramolecular nanoparticles (SNPs) with variable sizes (30–450 nm) from three different molecular building blocks using a cyclodextrin/adamantane recognition system. Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture).

original image

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