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One-Pot, Direct Incorporation of [11C]CO2 into Carbamates

Authors


  • This research was carried out at Brookhaven National Laboratory (contract DE-AC02-98CH10886 with the US Department of Energy and supported by its Office of Biological and Environmental Research). J.M.H. was supported by the NIH (1F32EB008320-01) and a Goldhaber Fellowship at BNL. A.T.R was supported by Deutscher Akademischer Austauschdienst (DAAD) and BNL.

Abstract

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of 11CO2 with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of 11C-labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

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