Financial support was provided by the NIHGMS (R01 GM078201-01-01), Merck, and Amgen. B.S. is grateful for a Merck predoctoral fellowship.
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Communication
Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis†
Article first published online: 11 MAY 2009
DOI: 10.1002/anie.200900220
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Simmons, B., Walji, A. and MacMillan, D. (2009), Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis. Angewandte Chemie International Edition, 48: 4349–4353. doi: 10.1002/anie.200900220
- †
Publication History
- Issue published online: 26 MAY 2009
- Article first published online: 11 MAY 2009
- Manuscript Received: 14 JAN 2009
Funded by
- NIHGMS. Grant Number: R01 GM078201-01-01
Keywords:
- cascade reactions;
- enantioselectivity;
- natural products;
- organocatalysis
Graphical Abstract
United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, -hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.
Abstract
United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, -hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.