Financial support was provided by the NIHGMS (R01 GM078201-01-01), Merck, and Amgen. B.S. is grateful for a Merck predoctoral fellowship.
Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis†
Article first published online: 11 MAY 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 24, pages 4349–4353, June 2, 2009
How to Cite
Simmons, B., Walji, Abbas M. and MacMillan, David W. C. (2009), Cycle-Specific Organocascade Catalysis: Application to Olefin Hydroamination, Hydro-oxidation, and Amino-oxidation, and to Natural Product Synthesis. Angew. Chem. Int. Ed., 48: 4349–4353. doi: 10.1002/anie.200900220
- Issue published online: 26 MAY 2009
- Article first published online: 11 MAY 2009
- Manuscript Received: 14 JAN 2009
- NIHGMS. Grant Number: R01 GM078201-01-01
- cascade reactions;
- natural products;
United in effort: The combined application of iminium (Im) and enamine (En) catalysts can effect a range of valuable asymmetric transformations including 1,2-hydroamination, -hydro-oxidation, and -amino-oxidation of olefins (see picture). An enantioselective organocascade catalysis was also applied in the synthesis of a complex natural product.