Communication

A New Two-Photon-Sensitive Block Copolymer Nanocarrier†

  1. Jérôme Babin Dr.2,
  2. Maxime Pelletier2,
  3. Martin Lepage Prof. Dr.3,
  4. Jean-François Allard1,
  5. Denis Morris Prof. Dr.1,
  6. Yue Zhao Prof. Dr.2

Article first published online: 2 APR 2009

DOI: 10.1002/anie.200900255

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 18, pages 3329–3332, April 20, 2009

Additional Information

How to Cite

Babin, J., Pelletier, M., Lepage, M., Allard, J.-F., Morris, D. and Zhao, Y. (2009), A New Two-Photon-Sensitive Block Copolymer Nanocarrier. Angewandte Chemie International Edition, 48: 3329–3332. doi: 10.1002/anie.200900255

Author Information

  1. 1

    Département de physique, Université de Sherbrooke, Sherbrooke, Québec, J1K2R1 (Canada)

  2. 2

    Département de chimie, Université de Sherbrooke, Sherbrooke, Québec, J1K2R1 (Canada), Fax: (+1) 819-821-8017, http://pages.usherbrooke.ca/yzhao/

  3. 3

    Département de médecine nucléaire et de radiobiologie and Centre d'imagerie moléculaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, J1K2R1 (Canada)

  1. †

    This work was supported by the Natural Sciences and Engineering Research Council of Canada, le Fonds québécois de la recherche sur la nature et les technologies of Québec via the Centre for Self-Assembled Chemical Structures (CSACS), the Cancer Research Society Inc. (Canada), and St-Jean Photochemicals (Quebec).

Publication History

  1. Issue published online: 15 APR 2009
  2. Article first published online: 2 APR 2009
  3. Manuscript Received: 15 JAN 2009

Funded by

  • Natural Sciences and Engineering Research Council of Canada
  • the Centre for Self-Assembled Chemical Structures (CSACS)
  • Cancer Research Society Inc. (Canada)
  • St-Jean Photochemicals (Quebec)

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Keywords:

  • block copolymers;
  • dyes and pigments;
  • micelles;
  • photochemistry;
  • photocontrollable release

Graphical Abstract

Thumbnail image of graphical abstract

Easily disrupted: Micelles of a new amphiphilic block copolymer that bear coumarin groups are sensitive to near infrared light by two-photon absorption of the chromophore. Disruption of the micelles under irradiation at 794 nm results in release of both photocleaved coumarin and encapsulated nile red from the hydrophobic core of micelle into aqueous solution, which results in opposing changes in fluorescence emission intensity.

Abstract

Easily disrupted: Micelles of a new amphiphilic block copolymer that bear coumarin groups are sensitive to near infrared light by two-photon absorption of the chromophore. Disruption of the micelles under irradiation at 794 nm results in release of both photocleaved coumarin and encapsulated nile red from the hydrophobic core of micelle into aqueous solution, which results in opposing changes in fluorescence emission intensity.

View Full Article with Supporting Information (HTML) Get PDF (415K)