Get access

Lost in Transcription—Inhibition of RNA Polymerase


  • We thank Rainer Endermann, Alexander Hillisch, and Guido Schiffer for stimulating scientific discussions and Robert Zahler for revising the English manuscript.


Form and function: The natural product myxopyronin A provides the key to understanding the inhibition of bacterial RNA polymerase and should spark new ideas for the design of new antibiotics against tuberculosis and other infectious diseases.

original image