Enantioselective Friedel–Crafts Reactions in Water Using a DNA-Based Catalyst

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  • Financial support from the NRSC-Catalysis is gratefully acknowledged.

Abstract

Taking the plunge: The first example of a Lewis acid catalyzed asymmetric Friedel–Crafts alkylation with olefins in water is described. By using loadings of a DNA-based copper catalyst as low as 0.15 mol %, good yields and excellent enantioselectivities were obtained in the reaction of α,β-unsaturated 2-acyl imidazoles with heteroaromatic π nucleophiles. dmbpy=4,4′-dimethyl-2,2′-bipyridine.

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