Communication

A Microreactor with Thousands of Subcompartments: Enzyme-Loaded Liposomes within Polymer Capsules†

  1. Brigitte Städler Dr.1,
  2. Rona Chandrawati1,
  3. Andrew D. Price Dr.1,
  4. Siow-Feng Chong1,
  5. Kerry Breheney2,
  6. Almar Postma Dr.1,
  7. Luke A. Connal Dr.1,
  8. Alexander N. Zelikin Dr.1,
  9. Frank Caruso Prof.1

Article first published online: 5 MAY 2009

DOI: 10.1002/anie.200900386

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 24, pages 4359–4362, June 2, 2009

Additional Information

How to Cite

Städler, B., Chandrawati, R., Price, A., Chong, S.-F., Breheney, K., Postma, A., Connal, L., Zelikin, A. and Caruso, F. (2009), A Microreactor with Thousands of Subcompartments: Enzyme-Loaded Liposomes within Polymer Capsules. Angewandte Chemie International Edition, 48: 4359–4362. doi: 10.1002/anie.200900386

Author Information

  1. 1

    Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010 (Australia), Fax: (+61) 3-8344-4153

  2. 2

    CSIRO, Molecular and Health Technologies, Parkville, Victoria 3052 (Australia)

  1. †

    This work was supported by the Swiss National Science Foundation (SNF, PBEZB-118906) and the Australian Research Council under the Federation Fellowship and Discovery Project schemes.

Publication History

  1. Issue published online: 26 MAY 2009
  2. Article first published online: 5 MAY 2009
  3. Manuscript Revised: 1 APR 2009
  4. Manuscript Received: 21 JAN 2009

Funded by

  • Swiss National Science Foundation. Grant Number: PBEZB-118906
  • Australian Research Council

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Keywords:

  • capsules;
  • cross-linking;
  • enzymes;
  • liposomes;
  • polymers

Graphical Abstract

Thumbnail image of graphical abstract

Fully loaded: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol-modified polymers allows the preparation of capsosomes—liposome-compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction confirmed the presence of active cargo within the capsosomes and was used to determine the number of subcompartments within this novel biomedical carrier system.

Abstract

Fully loaded: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol-modified polymers allows the preparation of capsosomes—liposome-compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction confirmed the presence of active cargo within the capsosomes and was used to determine the number of subcompartments within this novel biomedical carrier system.

View Full Article with Supporting Information (HTML) Get PDF (569K)