Communication

From Metal Binding to Nanoparticle Formation: Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry†

  1. Sebyung Kang Dr.2,
  2. Craig C. Jolley Dr.2,
  3. Lars O. Liepold2,
  4. Mark Young Prof.1,
  5. Trevor Douglas Prof.2

Article first published online: 19 MAY 2009

DOI: 10.1002/anie.200900437

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 26, pages 4772–4776, June 15, 2009

Additional Information

How to Cite

Kang, S., Jolley, C., Liepold, L., Young, M. and Douglas, T. (2009), From Metal Binding to Nanoparticle Formation: Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry. Angewandte Chemie International Edition, 48: 4772–4776. doi: 10.1002/anie.200900437

Author Information

  1. 1

    Department of Plant Science, Montana State University, Fax: (+1) 406-994-5117

  2. 2

    Department of Chemistry and Biochemistry, Center for BioInspired Nanomaterials, Montana State University, Bozeman, MT 59717 (USA), Fax: (+1) 406-994-5947

  1. †

    This research was supported in part by grants from HFSP (RGP61/2007), the NSF (CBET-0709358), ONR (N00014-03-1-0692), and DOE (DE-FG02-07ER46477).

Publication History

  1. Issue published online: 9 JUN 2009
  2. Article first published online: 19 MAY 2009
  3. Manuscript Revised: 7 APR 2009
  4. Manuscript Received: 22 JAN 2009

Funded by

  • HFSP. Grant Number: RGP61/2007
  • NSF. Grant Number: CBET-0709358
  • ONR. Grant Number: N00014-03-1-0692
  • DOE. Grant Number: DE-FG02-07ER46477

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Keywords:

  • biomimetic synthesis;
  • iron oxides;
  • mass spectrometry;
  • metal binding;
  • protein cages

Graphical Abstract

Thumbnail image of graphical abstract

Mass measurements of metal-mineralized protein cages allowed quantitative examination of the effects of metal-ion concentration on the final nanoparticle size. Modeling using a kinetic master equation suggests that particle growth involves both a binding phase and a growth phase (see picture; I: relative abundance; LiDps: a DNA binding protein; nFe: number of Fe atoms).

Abstract

Mass measurements of metal-mineralized protein cages allowed quantitative examination of the effects of metal-ion concentration on the final nanoparticle size. Modeling using a kinetic master equation suggests that particle growth involves both a binding phase and a growth phase (see picture; I: relative abundance; LiDps: a DNA binding protein; nFe: number of Fe atoms).

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