Communication

Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction†

  1. Tobias Gräwert Dr.1,
  2. Felix Rohdich Dr.1,
  3. Ingrid Span1,
  4. Adelbert Bacher Prof.1,
  5. Wolfgang Eisenreich Prof.1,
  6. Jörg Eppinger Dr.2,3,
  7. Michael Groll Prof.1

Article first published online: 30 JUN 2009

DOI: 10.1002/anie.200900548

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 31, pages 5756–5759, July 20, 2009

Additional Information

How to Cite

Gräwert, T., Rohdich, F., Span, I., Bacher, A., Eisenreich, W., Eppinger, J. and Groll, M. (2009), Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction. Angew. Chem. Int. Ed., 48: 5756–5759. doi: 10.1002/anie.200900548

Author Information

  1. 1

    Center for Integrated Protein Science, Lehrstuhl für Biochemie, Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching (Germany), Fax: (+49) 89-2891-3363

  2. 2

    Department Chemie, Technische Universität München (Germany)

  3. 3

    Current address: King Abdullah University of Science and Technology, KAUST Catalysis Center, Thuwal (Saudi Arabia)

  1. †

    We are grateful to Matthias Lee for developing the enzymatic assay, to Claudia Baier for recording cyclic voltammograms and to the staff of PXII at the Swiss Light Source (Villigen), in particular Clemens Schulze-Briese, for help during data collection. We thank the Hans-Fischer Gesellschaft and the Stifterverband für die Deutsche Wissenschaft (Projekt-Nr. 11047: Forschungsdozentur Molekulare Katalyse) for financial support.

Publication History

  1. Issue published online: 15 JUL 2009
  2. Article first published online: 30 JUN 2009
  3. Manuscript Revised: 25 MAR 2009
  4. Manuscript Received: 29 JAN 2009

Funded by

  • Hans-Fischer Gesellschaft
  • Stifterverband für die Deutsche Wissenschaft

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