SEARCH

SEARCH BY CITATION

Keywords:

  • alcohols;
  • aldol reactions;
  • asymmetric catalysis;
  • biocatalysis;
  • organocatalysis
Thumbnail image of graphical abstract

Biocompatible: A modular chemoenzymatic synthesis (see scheme) based on asymmetric organo- and biocatalytic reaction sequences allows the sequential construction of both stereogenic centers of 1,3-diols and leads to all four possible stereoisomers in enantiomerically pure form. The biocompatibility of the organocatalytic aldol reaction allows its direct use in the subsequent enzymatic reduction without the need for a work-up step.