SEARCH

SEARCH BY CITATION

Keywords:

  • Baeyer–Villiger oxidation;
  • domino reactions;
  • natural products;
  • oxy-Michael addition;
  • sigmatropic rearrangement

Abstract

Thumbnail image of graphical abstract

Let the dominos fall: Synthesis of the complex DFGH ring system of the title compounds has been accomplished. The approach features simple treatment of the key intermediate with a Brønsted base to afford the tetracyclic cage-shaped target in one pot through a four-step domino transformation (see scheme; Mc= monochloromesylate, MOM=methoxymethyl).