We thank the NIGMS (GM72566) for support of this work, Wyeth Research for a fellowship (to A.V.D.), Dr. Jeffery A. Byers and Christopher J. Morten (MIT) for insightful discussions, and Dr. Li Li (MIT) for obtaining mass spectra.
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Communication
Functionalized Templates for the Convergent Assembly of Polyethers: Synthesis of the HIJK Rings of Gymnocin A†
Article first published online: 8 MAY 2009
DOI: 10.1002/anie.200900924
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Van Dyke, A. and Jamison, T. (2009), Functionalized Templates for the Convergent Assembly of Polyethers: Synthesis of the HIJK Rings of Gymnocin A. Angewandte Chemie International Edition, 48: 4430–4432. doi: 10.1002/anie.200900924
- †
Publication History
- Issue published online: 26 MAY 2009
- Article first published online: 8 MAY 2009
- Manuscript Received: 16 JAN 2009
Funded by
- NIGMS. Grant Number: GM72566
- Wyeth Research
Keywords:
- cascade reactions;
- metathesis;
- natural products;
- polyethers;
- template synthesis
Graphical Abstract
Extension ladder: The successful application of epoxide-opening strategies towards the synthesis of ladder-type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn=benzyl).
Abstract
Extension ladder: The successful application of epoxide-opening strategies towards the synthesis of ladder-type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn=benzyl).