Get access

Rhodium-Mediated Decarboxylative Conjugate Addition of Fluorinated Benzoic Acids: Stoichiometric and Catalytic Transformations

Authors


  • Financial support for this research was provided by an ND EPSCoR seed grant (EPS-0447679) and the NDSU startup fund. We thank Dr. Angel Ugrinov for assistance with X-ray crystallographic analysis.

Abstract

original image

Depending on the bisphosphine ligand, the decarboxylation of 2,6-difluorinated benzoic acids with a RhI catalyst in the presence of an acrylic ester or acrylamide led preferentially to conjugate addition (product 1) or Heck–Mizoroki arylation (product 2; binap=2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl, diop=4,5-bis(diphenylphosphanylmethyl)-2,2-dimethyl-1,3-dioxolane).

Get access to the full text of this article

Ancillary