Communication

Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes†

  1. Zehui Cao Dr.2,‡,
  2. Rong Tong1,‡,
  3. Abhijit Mishra1,
  4. Weichen Xu2,
  5. Gerard C. L. Wong Prof.1,
  6. Jianjun Cheng Prof.1,
  7. Yi Lu Prof.1,2

Article first published online: 21 JUL 2009

DOI: 10.1002/anie.200901452

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 35, pages 6494–6498, August 17, 2009

Additional Information

How to Cite

Cao, Z., Tong, R., Mishra, A., Xu, W., Wong, Gerard C. L., Cheng, J. and Lu, Y. (2009), Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes. Angew. Chem. Int. Ed., 48: 6494–6498. doi: 10.1002/anie.200901452

Author Information

  1. 1

    Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W. Green Street, Urbana, IL 61801 (USA), Fax: (+1) 217-333-2736 http://www.matse.illinois.edu/faculty/wong/profile.htmlhttp://www.matse.illinois.edu/faculty/cheng/profile.html

  2. 2

    Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA), Fax: (+1) 217-244-3186 http://www.chemistry.illinois.edu/faculty/Yi_Lu.html

  1. ‡

    Z.C. and R.T. contributed equally to this work.

  1. †

    This work was supported by a National Science Foundation Nanoscale Science and Engineering Center grant (DMR-0117792). J.C. thanks support from the National Science Foundation Career Program (DMR-0748834) and the Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University)—Center for Nanoscale Science and Technology (CNST, UIUC).

  2. ‡

    Z.C. and R.T. contributed equally to this work.

Publication History

  1. Issue published online: 12 AUG 2009
  2. Article first published online: 21 JUL 2009
  3. Manuscript Revised: 6 JUN 2009
  4. Manuscript Received: 17 MAR 2009

Funded by

  • National Science Foundation Nanoscale Science and Engineering Center. Grant Number: DMR-0117792
  • National Science Foundation Career Program. Grant Number: DMR-0748834
  • Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University)—Center for Nanoscale Science and Technology (CNST, UIUC)

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Keywords:

  • aptamers;
  • cisplatin;
  • drug delivery;
  • liposomes
Thumbnail image of graphical abstract

Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolin-aptamer-conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.

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