Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes


  • This work was supported by a National Science Foundation Nanoscale Science and Engineering Center grant (DMR-0117792). J.C. thanks support from the National Science Foundation Career Program (DMR-0748834) and the Siteman Center for Cancer Nanotechnology Excellence (SCCNE, Washington University)—Center for Nanoscale Science and Technology (CNST, UIUC).


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Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolin-aptamer-conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote.