A Graphene Platform for Sensing Biomolecules

Authors

  • Chun-Hua Lu,

    1. The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135
    Search for more papers by this author
  • Huang-Hao Yang Prof.,

    1. The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135
    2. The First Institute of Oceanography, SOA, Qingdao, 266061 (P.R. China)
    Search for more papers by this author
  • Chun-Ling Zhu Dr.,

    1. The First Institute of Oceanography, SOA, Qingdao, 266061 (P.R. China)
    Search for more papers by this author
  • Xi Chen Prof.,

    1. The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135
    Search for more papers by this author
  • Guo-Nan Chen Prof.

    1. The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135
    Search for more papers by this author

  • This work was jointly supported by the National Natural Science Foundation of China (No. 20775019, No. 20735002) and the National Science and Technology Development Project (863 project No. 2006AA09Z168).

Abstract

Sensitive platform: The use of graphene oxide (GO) as a platform for the sensitive and selective detection of DNA and proteins is presented. The interaction of GO and dye-labeled single-stranded DNA leads to quenching of the dye fluorescence. Conversely, the presence of a target DNA or protein leads to the binding of the dye-labeled DNA and target, releasing the DNA from GO, thereby restoring the dye fluorescence (see picture).

original image

Ancillary