Communication

Light-Triggered Bioactivity in Three Dimensions†

  1. Takahiro Muraoka Dr.1,
  2. Chung-Yan Koh1,
  3. Honggang Cui Dr.3,
  4. Samuel I. Stupp Prof. Dr.1,2,3

Article first published online: 6 JUL 2009

DOI: 10.1002/anie.200901524

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 32, pages 5946–5949, July 27, 2009

Additional Information

How to Cite

Muraoka, T., Koh, C.-Y., Cui, H. and Stupp, S. (2009), Light-Triggered Bioactivity in Three Dimensions. Angewandte Chemie International Edition, 48: 5946–5949. doi: 10.1002/anie.200901524

Author Information

  1. 1

    Department of Chemistry, Northwestern University, Evanston, IL 60208 (USA), Fax: (+1) 847-491-3010

  2. 2

    Feinberg School of Medicine, Northwestern University, Evanston, IL 60208 (USA)

  3. 3

    Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 (USA)

  1. †

    This work was supported by the National Science Foundation under grant DMR-0505772 and by the Department of Energy under grant DE-FG02-00ER45810. T.M. thanks the JSPS for his Research Fellowship for Young Scientists. We thank L. Palmer for a fruitful discussion. We thank M. Greenfield for help with the rheometer and the following Northwestern University facilities for use of their instruments: BIF, EPIC, IMSERC, Keck, and MRC.

Publication History

  1. Issue published online: 22 JUL 2009
  2. Article first published online: 6 JUL 2009
  3. Manuscript Revised: 27 MAY 2009
  4. Manuscript Received: 19 MAR 2009

Funded by

  • National Science Foundation. Grant Number: DMR-0505772
  • Department of Energy. Grant Number: DE-FG02-00ER45810
  • JSPS

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Keywords:

  • amphiphiles;
  • epitopes;
  • gels;
  • peptides;
  • self-assembly

Graphical Abstract

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Photocleavage of a 2-nitrobenzyl group in a bioactive peptide amphiphile containing the Arg-Gly-Asp (RGD) epitope triggers a sol-to-gel transition as nanospheres are converted to nanofibers (see picture). This morphological change enhances the bioactivity of the nanostructures surrounding cells in three dimensions.

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