We thank the Alexander von Humboldt Foundation for financial support to A.L.S., Helmut Schlaad for surfactant donation, Wiebke Fischer and Andrea Schulz for TEM measurements
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Communication
Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties†
Article first published online: 20 AUG 2009
DOI: 10.1002/anie.200901583
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
Angewandte Chemie International Edition
Volume 48, Issue 41, pages 7540–7545, September 28, 2009
Additional Information
How to Cite
Sisson, Adam L., Steinhilber, D., Rossow, T., Welker, P., Licha, K. and Haag, R. (2009), Biocompatible Functionalized Polyglycerol Microgels with Cell Penetrating Properties. Angew. Chem. Int. Ed., 48: 7540–7545. doi: 10.1002/anie.200901583
- †
Publication History
- Issue published online: 23 SEP 2009
- Article first published online: 20 AUG 2009
- Manuscript Revised: 5 JUN 2009
- Manuscript Received: 23 MAR 2009
Funded by
- Alexander von Humboldt Foundation
Keywords:
- click chemistry;
- emulsions;
- endocytosis;
- nanostructures;
- polymerization
Gels for cells: A new method to produce biocompatible polyglycerol microgel nanoparticles with controllable size (25–100 nm, see picture, top) and a readily functionalizable surface is developed. Fluorescence imaging shows clear evidence for particle uptake by cells through endocytotic pathways and localization of the particles in the perinuclear region.