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One-Dimensional Gold Nanoparticle Arrays by Electrostatically Directed Organization Using Polypeptide Self-Assembly


  • This work was supported in part by the National Institutes of Health (1-R01-EB006006-01), the National Center for Research Resources (1-P20-RR017716-01; a component of the National Institutes of Health), and the US Department of Defense (ARL CMR Pochan (CCMT332157)). We acknowledge the W. M. Keck foundation for partial funding of the College of Engineering Electron Microscopy Lab at the University of Delaware. A portion of this work was performed at the DuPont–Northwestern–Dow Collaborative Access Team (DND-CAT) located at Sector 5 of the Advanced Photon Source (APS). DND-CAT is supported by E.I. DuPont de Nemours & Co., The Dow Chemical Company, and the State of Illinois. Use of the APS was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract no. DE-AC02-06CH11357. We acknowledge the support of Dr. Honggang Cui for X-ray data acquisition and Dr. Kirk Czymmek for assistance with the congo red assay.


original image

Evenly spaced arrays: The unique molecular architecture of a self-assembled polypeptide template allows the electrostatic deposition of nanoparticles with uniform interparticle spacing. The hierarchical self-assembly mode of the polypeptide results in the display of charged patches at periodic distances along the length of the fibril architecture (see picture).