This research was supported by NIH-NCI NanoSystems Biology Cancer Center (U54A119347).
Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells†
Article first published online: 21 OCT 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 47, pages 8970–8973, November 9, 2009
How to Cite
Wang, S., Wang, H., Jiao, J., Chen, K.-J., Owens, Gwen E., Kamei, K.-i., Sun, J., Sherman, David J., Behrenbruch, Christian P., Wu, H. and Tseng, H.-R. (2009), Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells. Angew. Chem. Int. Ed., 48: 8970–8973. doi: 10.1002/anie.200901668
- Issue published online: 4 NOV 2009
- Article first published online: 21 OCT 2009
- Manuscript Revised: 16 AUG 2009
- Manuscript Received: 27 MAR 2009
- NIH-NCI NanoSystems Biology Cancer Center. Grant Number: U54A119347
- cancer diagnosis;
- cell capture;
A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (anti-EpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cell-capture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).