Communication

Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells†

  1. Shutao Wang Dr.,
  2. Hao Wang Dr.,
  3. Jing Jiao Dr.,
  4. Kuan-Ju Chen,
  5. Gwen E. Owens,
  6. Ken-ichiro Kamei Dr.,
  7. Jing Sun Dr.,
  8. David J. Sherman,
  9. Christian P. Behrenbruch Prof.,
  10. Hong Wu Prof.,
  11. Hsian-Rong Tseng Prof.

Article first published online: 21 OCT 2009

DOI: 10.1002/anie.200901668

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 48, Issue 47, pages 8970–8973, November 9, 2009

Additional Information

How to Cite

Wang, S., Wang, H., Jiao, J., Chen, K.-J., Owens, Gwen E., Kamei, K.-i., Sun, J., Sherman, David J., Behrenbruch, Christian P., Wu, H. and Tseng, H.-R. (2009), Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells. Angew. Chem. Int. Ed., 48: 8970–8973. doi: 10.1002/anie.200901668

Author Information

  1. Crump Institute for Molecular Imaging (CIMI), Institute for Molecular Medicine (IMED), Department of Molecular and Medical Pharmacology, California NanoSystems Institute (CNSI), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770 (USA), Fax: (+1) 310-206-8975 http://labs.pharmacology.ucla.edu/tsenglab/

  1. †

    This research was supported by NIH-NCI NanoSystems Biology Cancer Center (U54A119347).

Publication History

  1. Issue published online: 4 NOV 2009
  2. Article first published online: 21 OCT 2009
  3. Manuscript Revised: 16 AUG 2009
  4. Manuscript Received: 27 MAR 2009

Funded by

  • NIH-NCI NanoSystems Biology Cancer Center. Grant Number: U54A119347

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Keywords:

  • cancer diagnosis;
  • cell capture;
  • nanostructures;
  • silicon
Thumbnail image of graphical abstract

A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (anti-EpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cell-capture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).

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