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Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells


  • This research was supported by NIH-NCI NanoSystems Biology Cancer Center (U54A119347).


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A grabby substrate: A 3D nanostructured substrate, namely, a silicon-nanopillar (SiNP) array coated with epithelial-cell adhesion-molecule antibody (anti-EpCAM), shows enhanced local topographic interactions between nanoscale cell-surface components and the substrates surface, resulting in enhanced cell-capture efficiency when employed to isolate viable cancer cells from whole-blood samples (see schematic and SEM image of a captured cancer cell).