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Keywords:

  • α-helix mimetics;
  • amyloid β-peptides;
  • diabetes;
  • helical structures;
  • proteomimetics
Thumbnail image of graphical abstract

Split personality: A series of oligoamide-based helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hIAPP=human IAPP.