These authors contributed equally.
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Communication
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A Powerful Chiral Counteranion Motif for Asymmetric Catalysis†
Article first published online: 13 MAY 2009
DOI: 10.1002/anie.200901768
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
García-García, P., Lay, F., García-García, P., Rabalakos, C. and List, B. (2009), A Powerful Chiral Counteranion Motif for Asymmetric Catalysis. Angew. Chem. Int. Ed., 48: 4363–4366. doi: 10.1002/anie.200901768
- †
Funding by the Max-Planck-Society, the DFG (Priority Program 1179, Organocatalysis), the Fond der Chemischen Industrie, and the Spanish Ministerio de Educación y Ciencia (Fellowship to PiGG and PaGG) is gratefully acknowledged. We thank Sebastian Hoffmann for his early contributions to our studies and our HPLC department for their support.
- ‡
These authors contributed equally.
Publication History
- Issue published online: 26 MAY 2009
- Article first published online: 13 MAY 2009
- Manuscript Received: 1 APR 2009
Funded by
- Max-Planck-Society
- DFG
- Fond der Chemischen Industrie
- Spanish Ministerio de Educación y Ciencia
Keywords:
- disulfonimides;
- homogeneous catalysis;
- Mukaiyama aldol reaction;
- organocatalysis
Abstract
Room to swing a cat: A chiral disulfonimide has been designed as a powerful new motif for asymmetric catalysis. As a first illustration, a highly efficient and enantioselective Mukaiyama aldol reaction has been developed (see scheme). The actual catalyst is proposed to be an N-silyl imide which is generated in situ.