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Keywords:

  • disulfonimides;
  • homogeneous catalysis;
  • Mukaiyama aldol reaction;
  • organocatalysis

Abstract

Thumbnail image of graphical abstract

Room to swing a cat: A chiral disulfonimide has been designed as a powerful new motif for asymmetric catalysis. As a first illustration, a highly efficient and enantioselective Mukaiyama aldol reaction has been developed (see scheme). The actual catalyst is proposed to be an N-silyl imide which is generated in situ.