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Keywords:

  • allyl silanes;
  • asymmetric synthesis;
  • cyclization;
  • fluorination;
  • oxidative cleavage
Thumbnail image of graphical abstract

A refreshing cascade: General fluorocyclization reactions will breathe new life into the use of fluorinated hetero- and carbocycles as pharmaceuticals and agrochemicals. Allyl silanes have now been shown to undergo fluorination–cyclization with N[BOND]F reagents to give cis- and trans-substituted fluorinated heterocycles selectively (see scheme). The correct choice of silyl group was critical to prevent competitive fluorodesilylation.