Gold-Nanoparticle-Based Multicolor Nanobeacons for Sequence-Specific DNA Analysis


  • This work was supported by the National Natural Science Foundation (20725516, 20873175, 60537030), Ministry of Science and Technology (2006CB933000, 2007CB936000, 2007AA06A406), Ministry of Health (2009ZX10004-301), and Shanghai Municipal Commission for Science and Technology (0952nm04600, 08jc1422600).


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Color vision: Multicolor molecular beacons are constructed from relatively large gold nanoparticles self-assembled with stem–loop probes and helper oligonucleotides (see picture). The nanobeacons can respond differentially to multiple DNA targets, emitting multiple colors.