Constructing and Exploiting the Fluorescent Protein Paintbox (Nobel Lecture)

Authors

  • Roger Y. Tsien Prof.

    1. Howard Hughes Medical Institute and Departments of Pharmacology and Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0647 (USA)
    Search for more papers by this author

  • Copyright© The Nobel Foundation 2008. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.

Abstract

original image

Trip the light fantastic: The green fluorescent protein (GFP) is an invaluable tool for biochemical and medicinal research. It can make tumors, amyloid plaques from Alzheimer′s disease, or pathogenic bacteria equally visible. Ground-breaking contributions in this field have resulted in the 2008 Nobel Prize for Chemistry being awarded to Osamu Shimomura, Martin Chalfie, and Roger Tsien. The Nobel Laureates describe their research first-hand.

Ancillary