The Ruthenium-Catalyzed Hydrovinylation of Internal Alkynes by Acrylates: An Atom Economic Approach to Highly Substituted 1,3-Dienes


  • The authors are grateful to the Deutsche Forschungsgemeinschaft (SFB706), the Fonds der Chemischen Industrie, the Deutsche Krebshilfe and the Dr.-Otto-Röhm-Gedächtnisstiftung for generous financial support of their work.


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Atom economy made easy: After in situ activation, a simple air- and moisture-stable complex derived from RuCl3 and PPh3, catalyzes the hydrovinylation of a variety of terminal and internal alkynes with substituted acrylates in good to excellent yields and regioselectivities (see scheme).