We thank Dr. Takehiro Suzuki (Biomolecular Characterization Team, RIKEN) for MALDI-TOF mass spectrometry and Dr. Yayoi Hongo (Molecular Characterization Team, RIKEN) for ESI mass spectrometry.
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Communication
Exciton-Controlled Hybridization-Sensitive Fluorescent Probes: Multicolor Detection of Nucleic Acids†
Article first published online: 27 JUL 2009
DOI: 10.1002/anie.200902000
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Ikeda, S., Kubota, T., Yuki, M. and Okamoto, A. (2009), Exciton-Controlled Hybridization-Sensitive Fluorescent Probes: Multicolor Detection of Nucleic Acids. Angewandte Chemie International Edition, 48: 6480–6484. doi: 10.1002/anie.200902000
- †
Publication History
- Issue published online: 12 AUG 2009
- Article first published online: 27 JUL 2009
- Manuscript Received: 15 APR 2009
Keywords:
- bioorganic chemistry;
- excitonic interaction;
- fluorescent probes;
- nucleic acids;
- RNA
Graphical Abstract
A colorful bunch: A series of fluorescent probes designed on the basis of fluorescence quenching caused by an excitonic interaction contain different dye moieties and fluoresce in various colors upon hybridization with their target nucleic acid. The picture shows simultaneous fluorescence in three colors in the nucleus of a cell containing an excess of three different microRNA strands. Left: differential interference contrast image.