Nickel-Catalyzed Three-Component [2+2+2] Cycloaddition Reaction of Arynes, Alkenes, and Alkynes

Authors

  • Zaozao Qiu,

    1. Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
    Search for more papers by this author
  • Zuowei Xie Prof. Dr.

    1. Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
    Search for more papers by this author

  • This work was supported by grants from the Research Grants Council of the Hong Kong Special Administration Region (Project No. 404108) and the Chinese University of Hong Kong.

Abstract

original image

Three in one: Nickel-catalyzed three-component cycloaddition reactions of readily available arynes, activated alkenes, and alkynes gave a series of substituted 1,2-dihydronaphthalenes in moderate to very good yields with excellent chemo- and regioselectivity (see scheme, TMS=trimethylsilyl, cod=1,5-cyclooctadiene).

Ancillary