We thank Elaine Gee for critically reading the manuscript. K.E.G. is supported by a Liebig scholarship of the FCI, M.H. is supported by the IDK-NBT.
The Transmembrane Structure of Integrin αIIbβ3: Significance for Signal Transduction†
Article first published online: 13 JUL 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 36, pages 6590–6593, August 24, 2009
How to Cite
Hoefling, M., Kessler, H. and Gottschalk, K.-E. (2009), The Transmembrane Structure of Integrin αIIbβ3: Significance for Signal Transduction. Angew. Chem. Int. Ed., 48: 6590–6593. doi: 10.1002/anie.200902016
- Issue published online: 19 AUG 2009
- Article first published online: 13 JUL 2009
- Manuscript Received: 15 APR 2009
- cell adhesion;
- computational prediction;
- membrane proteins;
- signal transduction
Outside contact: Cells in multicellular organisms regulate their adhesion through specialized integrin receptors, which relay signals bidirectionally between the inside and outside of cells. The transmembrane domains (see picture, blue; the integrin–talin complex is red and green) of integrins are the center of the signaling process. Recently, structures of these domains have been reported that shed light on the signal transduction mechanism.