The Transmembrane Structure of Integrin αIIbβ3: Significance for Signal Transduction


  • We thank Elaine Gee for critically reading the manuscript. K.E.G. is supported by a Liebig scholarship of the FCI, M.H. is supported by the IDK-NBT.


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Outside contact: Cells in multicellular organisms regulate their adhesion through specialized integrin receptors, which relay signals bidirectionally between the inside and outside of cells. The transmembrane domains (see picture, blue; the integrin–talin complex is red and green) of integrins are the center of the signaling process. Recently, structures of these domains have been reported that shed light on the signal transduction mechanism.