We thank the Leverhulme Trust for a Fellowship (J.M.B.).
Transition-Metal-Mediated Reactions for CF Bond Construction: The State of Play†
Article first published online: 13 OCT 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 46, pages 8610–8614, November 2, 2009
How to Cite
Brown, John M. and Gouverneur, V. (2009), Transition-Metal-Mediated Reactions for CF Bond Construction: The State of Play. Angew. Chem. Int. Ed., 48: 8610–8614. doi: 10.1002/anie.200902121
- Issue published online: 28 OCT 2009
- Article first published online: 13 OCT 2009
- Manuscript Received: 20 APR 2009
- Leverhulme Trust
- homogeneous catalysis;
- transition metals
It′s a rate thing: Crucial conceptual advances have allowed for the development of a Pd-mediated pathway to CarylF by using either electrophilic (right) or nucleophilic (left) fluorinating reagents. Of significance is the recognition that PdIV intermediates reduce the barrier to CF reductive elimination and the use of an ancillary bulky ligand to force reductive elimination from a 14-electron PdII complex.