Transition-Metal-Mediated Reactions for Cmath image[BOND]F Bond Construction: The State of Play


  • We thank the Leverhulme Trust for a Fellowship (J.M.B.).


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It′s a rate thing: Crucial conceptual advances have allowed for the development of a Pd-mediated pathway to Caryl[BOND]F by using either electrophilic (right) or nucleophilic (left) fluorinating reagents. Of significance is the recognition that PdIV intermediates reduce the barrier to C[BOND]F reductive elimination and the use of an ancillary bulky ligand to force reductive elimination from a 14-electron PdII complex.