Microfluidic Formation of Monodisperse, Cell-Sized, and Unilamellar Vesicles


  • We thank Dr. Andrew S. Utada for helpful discussions. This work was partly supported by Grants-in-Aid for Scientific Research on Priority Areas (innovative nanoscience) from Ministry of Education, Culture, Sports, Science, and Technology Japan and Kanagawa Academy of Science and Technology (KAST) (Japan).


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Gently down the stream: A microfluidic technique uses a continuous fluid stream to generate monodisperse unilamellar phospholipid vesicles from a single bilayer (see picture). Since the vesicles are robust and efficiently encapsulate high concentrations of various molecules, they are useful as delivery vehicles and as model cellular systems.