Total Synthesis of (+)-Haplophytine


  • This work was financially supported by the KAKENHI, a Grant-in-Aid for Scientific Research (B) (20390003), the Uehara Memorial Foundation, the Kato Memorial Bioscience Foundation, and the JSPS (predoctoral fellowship to H.U.).


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Advancing alkaloid synthesis: (+)-Haplophytine (see structure) was the target of a total synthesis featuring a highly stereoselective intramolecular Mannich reaction, Friedel–Crafts alkylation, oxidative rearrangement, and Fischer indole synthesis.