Get access

Heck Reactions with Palladium Nanoparticles in Ionic Liquids: Coupling of Aryl Chlorides with Deactivated Olefins


  • This research was in part financially supported by the University of Bari.


original image

Smooth operators: Heck reactions of aryl chlorides were catalyzed by ligand-free palladium acetate in a molten mixture of tetraalkylammonium ionic liquids under aerobic and relatively mild conditions (see example). Deactivated electron-rich aryl chlorides reacted with a wide array of substituted alkenes under these conditions, which thus enabled the coupling of combinations of substrates that are commonly unreactive with traditional catalysts.