We thank Dr. T.-L. Huh (The Korea Zebrafish Organogenesis Mutant Bank) for technical assistance with the zebrafish studies and for providing Tg(cmlc2:GFP) transgenic zebrafish and cmlc2- and vmhc-containing plasmids. This work was supported by grants of the NRL and WCU (R32-2008-000-10217-0) programs (KOSEF/MEST). S.-K.K. thanks the Seoul Science Fellowship program. S.-K.K. and X.Z.T. also thank the BK21 program (KRF).
Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications†
Article first published online: 15 SEP 2009
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 42, pages 7809–7812, October 5, 2009
How to Cite
Ko, S.-K., Jin, H., Jung, D.-W., Tian, X. and Shin, I. (2009), Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications. Angew. Chem. Int. Ed., 48: 7809–7812. doi: 10.1002/anie.200902370
- Issue published online: 30 SEP 2009
- Article first published online: 15 SEP 2009
- Manuscript Revised: 25 JUL 2009
- Manuscript Received: 4 MAY 2009
- WCU. Grant Number: R32-2008-000-10217-0
- chemical genetics;
- combinatorial chemistry;
A change of heart: Cardiosulfa, a small molecule that induces heart deformation during zebrafish development, has been identified by using a forward chemical-genetic approach. Zebrafish embryos exposed to cardiosulfa have a narrow and elongated heart within an enlarged pericardial sac (see picture; heart marked with green fluorescent protein).