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Cardiosulfa, a Small Molecule that Induces Abnormal Heart Development in Zebrafish, and Its Biological Implications


  • We thank Dr. T.-L. Huh (The Korea Zebrafish Organogenesis Mutant Bank) for technical assistance with the zebrafish studies and for providing Tg(cmlc2:GFP) transgenic zebrafish and cmlc2- and vmhc-containing plasmids. This work was supported by grants of the NRL and WCU (R32-2008-000-10217-0) programs (KOSEF/MEST). S.-K.K. thanks the Seoul Science Fellowship program. S.-K.K. and X.Z.T. also thank the BK21 program (KRF).


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A change of heart: Cardiosulfa, a small molecule that induces heart deformation during zebrafish development, has been identified by using a forward chemical-genetic approach. Zebrafish embryos exposed to cardiosulfa have a narrow and elongated heart within an enlarged pericardial sac (see picture; heart marked with green fluorescent protein).

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