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Keywords:

  • cell encapsulation;
  • collagen peptides;
  • metal–organic frameworks;
  • self-assembly;
  • three-dimensional scaffolds
Thumbnail image of graphical abstract

It won′t overstay its welcome: Metal ions trigger the rapid assembly of a triple-helical collagen-based peptide with ligands at the ends and center into a fibrous three-dimensional mesh under physiological conditions (see picture). Importantly for applications in regenerative medicine, a mild chelating agent causes rapid disassembly of the mesh. Human endothelial cells were readily encapsulated and cultured within the collagen-peptide network.